Elevated levels of the bone-derived hormone FGF23 are a hallmark of both inherited phosphate-wasting disorders such as XLH and chronic kidney disease (CKD), where they predict disease progression and mortality.
This project investigates the mechanisms driving increased FGF23 secretion in bone and its maladaptive signaling in the diseased kidney. Using Hyp and CKD mouse models, we combine spatial multi-omics technologies with computational systems medicine.
The results will provide new insights into FGF23 biology and may contribute to improved therapeutic strategies for XLH and CKD patients.
We are currently hiring
Reinhold Erben
Axel Walch
Jan Baumbach
Grant IDs
DFG:565905120
